![Mechanisms of Lactone Hydrolysis in Neutral and Alkaline Conditions | The Journal of Organic Chemistry Mechanisms of Lactone Hydrolysis in Neutral and Alkaline Conditions | The Journal of Organic Chemistry](https://pubs.acs.org/cms/10.1021/jo400258w/asset/images/large/jo-2013-00258w_0011.jpeg)
Mechanisms of Lactone Hydrolysis in Neutral and Alkaline Conditions | The Journal of Organic Chemistry
![organic chemistry - Mechanism of three-membered lactone hydrolysis in base - Chemistry Stack Exchange organic chemistry - Mechanism of three-membered lactone hydrolysis in base - Chemistry Stack Exchange](https://i.stack.imgur.com/pRsja.png)
organic chemistry - Mechanism of three-membered lactone hydrolysis in base - Chemistry Stack Exchange
![Improving Pseudomonas fluorescens esterase for hydrolysis of lactones - Catalysis Science & Technology (RSC Publishing) DOI:10.1039/C7CY01770G Improving Pseudomonas fluorescens esterase for hydrolysis of lactones - Catalysis Science & Technology (RSC Publishing) DOI:10.1039/C7CY01770G](https://pubs.rsc.org/image/article/2017/CY/c7cy01770g/c7cy01770g-f1_hi-res.gif)
Improving Pseudomonas fluorescens esterase for hydrolysis of lactones - Catalysis Science & Technology (RSC Publishing) DOI:10.1039/C7CY01770G
![Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic? Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic?](https://www.researchgate.net/profile/Md-Imteyaz-Alam/post/Why_does_ring_opening_reaction_of_lactones_often_follow_nucleophilic_pathway_and_not_electrophilic/attachment/59d622dcc49f478072e99174/AS%3A272119852666883%401441889836668/download/GVL+ring+opening.jpg)
Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic?
![Table 4 from Mechanisms of lactone hydrolysis in neutral and alkaline conditions. | Semantic Scholar Table 4 from Mechanisms of lactone hydrolysis in neutral and alkaline conditions. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/8b57fe7d6a5984cbeb43a275161918f8d7fa73b5/8-Table4-1.png)
Table 4 from Mechanisms of lactone hydrolysis in neutral and alkaline conditions. | Semantic Scholar
![Mechanisms of Lactone Hydrolysis in Neutral and Alkaline Conditions | The Journal of Organic Chemistry Mechanisms of Lactone Hydrolysis in Neutral and Alkaline Conditions | The Journal of Organic Chemistry](https://pubs.acs.org/cms/10.1021/jo400258w/asset/images/medium/jo-2013-00258w_0013.gif)
Mechanisms of Lactone Hydrolysis in Neutral and Alkaline Conditions | The Journal of Organic Chemistry
![SOLVED:Draw a curved arrow mechanism for the hydrolysis of the following lactone (cycic ester) in base_ Hzo H8 (cat) OH Create OscerSketch Answer 4 This is a trans-esterfication where one ester is SOLVED:Draw a curved arrow mechanism for the hydrolysis of the following lactone (cycic ester) in base_ Hzo H8 (cat) OH Create OscerSketch Answer 4 This is a trans-esterfication where one ester is](https://cdn.numerade.com/ask_images/a4900d1ade0a4274bf3b0c0da877028f.jpg)
SOLVED:Draw a curved arrow mechanism for the hydrolysis of the following lactone (cycic ester) in base_ Hzo H8 (cat) OH Create OscerSketch Answer 4 This is a trans-esterfication where one ester is
![organic chemistry - Mechanism of three-membered lactone hydrolysis in base - Chemistry Stack Exchange organic chemistry - Mechanism of three-membered lactone hydrolysis in base - Chemistry Stack Exchange](https://i.stack.imgur.com/fDJC6.png)
organic chemistry - Mechanism of three-membered lactone hydrolysis in base - Chemistry Stack Exchange
![Molecules | Free Full-Text | Mechanisms of a Cyclobutane-Fused Lactone Hydrolysis in Alkaline and Acidic Conditions Molecules | Free Full-Text | Mechanisms of a Cyclobutane-Fused Lactone Hydrolysis in Alkaline and Acidic Conditions](https://www.mdpi.com/molecules/molecules-26-03519/article_deploy/html/images/molecules-26-03519-sch001.png)
Molecules | Free Full-Text | Mechanisms of a Cyclobutane-Fused Lactone Hydrolysis in Alkaline and Acidic Conditions
![Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic? Why does ring opening reaction (of lactones) often follow nucleophilic pathway and not electrophilic?](https://www.researchgate.net/profile/Md-Imteyaz-Alam/post/Why_does_ring_opening_reaction_of_lactones_often_follow_nucleophilic_pathway_and_not_electrophilic/attachment/59d62923c49f478072e9c151/AS%3A272467027791893%401441972609852/image/El+RO1.jpg)