![Roscovitine has anti-proliferative and pro-apoptotic effects on glioblastoma cell lines: A pilot study Roscovitine has anti-proliferative and pro-apoptotic effects on glioblastoma cell lines: A pilot study](https://www.spandidos-publications.com/article_images/or/34/3/OR-34-03-1549-g02.jpg)
Roscovitine has anti-proliferative and pro-apoptotic effects on glioblastoma cell lines: A pilot study
![Cells | Free Full-Text | Cellular and Molecular Mechanisms of R/S- Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells | HTML Cells | Free Full-Text | Cellular and Molecular Mechanisms of R/S- Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells | HTML](https://www.mdpi.com/cells/cells-10-00104/article_deploy/html/images/cells-10-00104-ag.png)
Cells | Free Full-Text | Cellular and Molecular Mechanisms of R/S- Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells | HTML
![Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. - Abstract - Europe PMC Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. - Abstract - Europe PMC](https://europepmc.org/articles/PMC4800827/bin/jin-0008-0330-g03.jpg)
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. - Abstract - Europe PMC
![Mechanism of action of novel medical treatments for Cushing's disease.... | Download Scientific Diagram Mechanism of action of novel medical treatments for Cushing's disease.... | Download Scientific Diagram](https://www.researchgate.net/profile/Maria-Fleseriu/publication/308089506/figure/fig1/AS:406270466117632@1473873835025/Mechanism-of-action-of-novel-medical-treatments-for-Cushings-disease-From-left-to.png)
Mechanism of action of novel medical treatments for Cushing's disease.... | Download Scientific Diagram
![The binding pockets and interaction mechanisms of roscovitine in free... | Download Scientific Diagram The binding pockets and interaction mechanisms of roscovitine in free... | Download Scientific Diagram](https://www.researchgate.net/publication/275722986/figure/fig10/AS:614085569806365@1523420817498/The-binding-pockets-and-interaction-mechanisms-of-roscovitine-in-free-and-phosphorylated.png)
The binding pockets and interaction mechanisms of roscovitine in free... | Download Scientific Diagram
![Model depicting mechanism of action of R-Roscovitine and its inhibition... | Download Scientific Diagram Model depicting mechanism of action of R-Roscovitine and its inhibition... | Download Scientific Diagram](https://www.researchgate.net/profile/Chit-Fang-Cheok/publication/5870101/figure/fig5/AS:280345061675032@1443850879822/Model-depicting-mechanism-of-action-of-R-Roscovitine-and-its-inhibition-of-the-NF-B.png)
Model depicting mechanism of action of R-Roscovitine and its inhibition... | Download Scientific Diagram
![R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages | Scientific Reports R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages | Scientific Reports](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41598-020-78817-x/MediaObjects/41598_2020_78817_Fig1_HTML.png)
R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages | Scientific Reports
![Kinase inhibitor roscovitine as a PB2 cap-binding inhibitor against influenza a virus replication - ScienceDirect Kinase inhibitor roscovitine as a PB2 cap-binding inhibitor against influenza a virus replication - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006291X20307567-fx1.jpg)
Kinase inhibitor roscovitine as a PB2 cap-binding inhibitor against influenza a virus replication - ScienceDirect
![Interactions of (R)-roscovitine with PDXK (A and B) and CDK2 (C and D).... | Download Scientific Diagram Interactions of (R)-roscovitine with PDXK (A and B) and CDK2 (C and D).... | Download Scientific Diagram](https://www.researchgate.net/profile/Laurent-Meijer/publication/7759366/figure/fig3/AS:394428721188873@1471050543666/Interactions-of-R-roscovitine-with-PDXK-A-and-B-and-CDK2-C-and-D-A-detailed.png)
Interactions of (R)-roscovitine with PDXK (A and B) and CDK2 (C and D).... | Download Scientific Diagram
![Hypothetic scheme of cell death induction pathway triggered roscovitine... | Download Scientific Diagram Hypothetic scheme of cell death induction pathway triggered roscovitine... | Download Scientific Diagram](https://www.researchgate.net/profile/Laurent-Meijer/publication/51511885/figure/fig9/AS:601656999825416@1520457615058/Hypothetic-scheme-of-cell-death-induction-pathway-triggered-roscovitine-and-CR8-in-human.png)
Hypothetic scheme of cell death induction pathway triggered roscovitine... | Download Scientific Diagram
![Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models | Scientific Reports Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models | Scientific Reports](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41598-019-43111-y/MediaObjects/41598_2019_43111_Fig1_HTML.png)
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models | Scientific Reports
![Frontiers | Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs | Pharmacology Frontiers | Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs | Pharmacology](https://www.frontiersin.org/files/Articles/438151/fphar-10-00055-HTML-r1/image_m/fphar-10-00055-g001.jpg)
Frontiers | Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs | Pharmacology
![A). Development of Roscovitine and Purvalanol. (B). Crystal structure... | Download Scientific Diagram A). Development of Roscovitine and Purvalanol. (B). Crystal structure... | Download Scientific Diagram](https://www.researchgate.net/profile/Tahir-Chohan/publication/268230630/figure/fig1/AS:667716889374720@1536207520860/Fig-3-A-Development-of-Roscovitine-and-Purvalanol-B-Crystal-structure-of-CDK2.png)
A). Development of Roscovitine and Purvalanol. (B). Crystal structure... | Download Scientific Diagram
![Safety and pharmacokinetics of Roscovitine (Seliciclib) in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa, a randomized, placebo-controlled study - Journal of Cystic Fibrosis Safety and pharmacokinetics of Roscovitine (Seliciclib) in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa, a randomized, placebo-controlled study - Journal of Cystic Fibrosis](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/0cb8615a-8ae1-48da-93e6-251a849cbf7b/gr1_lrg.jpg)
Safety and pharmacokinetics of Roscovitine (Seliciclib) in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa, a randomized, placebo-controlled study - Journal of Cystic Fibrosis
![Dr. Pankaj Shah Prof&HOD Department of nephrolgy &Transplant Medicine Prevention of cyst progression in Autosomal dominant polycystic kidney disease. - ppt download Dr. Pankaj Shah Prof&HOD Department of nephrolgy &Transplant Medicine Prevention of cyst progression in Autosomal dominant polycystic kidney disease. - ppt download](https://images.slideplayer.com/36/10671750/slides/slide_19.jpg)
Dr. Pankaj Shah Prof&HOD Department of nephrolgy &Transplant Medicine Prevention of cyst progression in Autosomal dominant polycystic kidney disease. - ppt download
![Roscovitine induces up-regulation of both pro-and antiapoptotic BCL-2... | Download Scientific Diagram Roscovitine induces up-regulation of both pro-and antiapoptotic BCL-2... | Download Scientific Diagram](https://www.researchgate.net/profile/Michal-Koc-2/publication/230566702/figure/fig3/AS:667855200735235@1536240496157/Roscovitine-induces-up-regulation-of-both-pro-and-antiapoptotic-BCL-2-family-proteins-at.png)
Roscovitine induces up-regulation of both pro-and antiapoptotic BCL-2... | Download Scientific Diagram
![Roscovitine (Seliciclib,CYC202) | CAS:186692-46-6 | CDK inhibitor,potent and selective | High Purity | Manufacturer BioCrick Roscovitine (Seliciclib,CYC202) | CAS:186692-46-6 | CDK inhibitor,potent and selective | High Purity | Manufacturer BioCrick](https://www.biocrick.com/media/images/struct3D/BCC1105.png)
Roscovitine (Seliciclib,CYC202) | CAS:186692-46-6 | CDK inhibitor,potent and selective | High Purity | Manufacturer BioCrick
![Model depicting mechanism of action of R-Roscovitine and its inhibition... | Download Scientific Diagram Model depicting mechanism of action of R-Roscovitine and its inhibition... | Download Scientific Diagram](https://www.researchgate.net/profile/Chit-Fang-Cheok/publication/5870101/figure/fig5/AS:280345061675032@1443850879822/Model-depicting-mechanism-of-action-of-R-Roscovitine-and-its-inhibition-of-the-NF-B_Q640.jpg)
Model depicting mechanism of action of R-Roscovitine and its inhibition... | Download Scientific Diagram
![Frontiers | Playing the Whack-A-Mole Game: ERK5 Activation Emerges Among the Resistance Mechanisms to RAF-MEK1/2-ERK1/2- Targeted Therapy | Cell and Developmental Biology Frontiers | Playing the Whack-A-Mole Game: ERK5 Activation Emerges Among the Resistance Mechanisms to RAF-MEK1/2-ERK1/2- Targeted Therapy | Cell and Developmental Biology](https://www.frontiersin.org/files/MyHome%20Article%20Library/647311/647311_Thumb_400.jpg)
Frontiers | Playing the Whack-A-Mole Game: ERK5 Activation Emerges Among the Resistance Mechanisms to RAF-MEK1/2-ERK1/2- Targeted Therapy | Cell and Developmental Biology
![Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. - Abstract - Europe PMC Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. - Abstract - Europe PMC](https://europepmc.org/articles/PMC4800827/bin/jin-0008-0330-g01.jpg)
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. - Abstract - Europe PMC
![Roscovitine attenuates intimal hyperplasia via inhibiting NF-κB and STAT3 activation induced by TNF-α in vascular smooth muscle cells - ScienceDirect Roscovitine attenuates intimal hyperplasia via inhibiting NF-κB and STAT3 activation induced by TNF-α in vascular smooth muscle cells - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006295217302356-fx1.jpg)